General Cell Lines and Cell Cultures
ATCC Neisseria gonorrhoeae
Neisseria gonorrhoeae strain CDC Ng-98 was isolated from a cervix. This whole-genome sequenced bacterial strain can be used in infectious disease research, media testing, and sexually transmitted disease research.
Biochain Institute Inc Multiple Tumor Tissue Array - Bladder, Colon, Kidney, Lung, Stomach, and Uterus tumors, 2 slides/PK
BioChain's tissue arrays or tissue microarrays (TMAs) are a useful tool in biomarker research and drug target validation. It consists of paraffin blocks that are assembled in array fashion to allow multiplex histological analysis. BioChain's TMAs provide a valuable tool for analysis of protein, RNA, or DNA molecules in oncology, both the malignant and metastatic markers. TMAs can also be constructed with tissues from other diseases and species.
ATCC Phoenix-ECO; Embryonic Kidney Cells; Human (Homo sapiens)
Phoenix-ECO is an epithelial cell line that was isolated in 1996 from the kidney of an embryo. This cell line was deposited by G Nolan and can be used in vaccine development research.
ATCC HL-60; Promyelocytic Leukemia; Human (Homo sapiens)
HL-60 cells are promyeoloblasts isolated from the peripheral blood by leukopheresis from a 36-year-old,White, female with acute promyelocytic leukemia. This cell line can be used in immune disorder and immunology research.
Eurofins Discoverx cAMP Hunter CHO-K1 GPR81 Gi Cell Line, 2 vials. (95-0149C2)
The cAMP Hunter GPR81 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. L-lactate) based activation of GPR81 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GPR81, a naturally Gi/Go coupled GPCR. Upon activation of GPR81, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ACROBiosystems CHO/Human PD-L1 Stable Cell Line (High Expression) Development Service
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Eurofins Discoverx PathHunter U2OS β-Catenin Nuclear Translocation Cell Line, 2 vials. (93-0743C3)
The PathHunter U2OS β-Catenin Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the Wnt-FzGSK3β pathway. This cell line enables assessment of ligand (e.g. wnt 3a) based pathway activation via detection of resulting β-Catenin nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged β-Catenin and nuclear localized EA. Upon pathway activation, induced nuclear translocation of β-Catenin leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Genscript Corporation CHO-K1/ITGAE Stable Cell Line
Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human ITGAE is expressed widely on intraepithelial lymphocyte (IEL) T cells (both T cells and T cells) and on some peripheral regulatory T cells (Tregs) It has also been reported on lamina propria T cells A subset of dendritic cells in the gut mucosa and mesenteric lymph nodes known as CD103 dendritic cells also expresses this marker
ATCC Klebsiella pneumoniae; Strain 1002565
Klebsiella pneumoniae subsp. pneumoniae strain 1002565 is a whole-genome sequenced bacterium that was isolated from a respiratory sample. This strain is resistant to ertapenem and imipenem and was confirmed by PCR to contain the blaNDM gene. This bacterial culture can be used in antimicrobial resistance research, drug development, infectious disease research, and respiratory disease research.
Eurofins Discoverx KILR SKOV3 Cell Pool, 2 vials. (97-1007P023)
The KILR SKOV3 cell pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint modulators, bispecifics, CAR-T, etc.) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell pool is a heterogeneous population of SKOV3 cells that overexpress a ProLabel-tagged housekeeping gene. Upon effector cells-mediated cell lysis, ProLabel is released to the media, where EA in the detection kit produces an EFC signal proportional to the level of ProLabel released. This allows for calculation of percent lysis of the KILR cell pool. This stable cell pool is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kilr.
Genscript Corporation CHO-K1/ADRA2B/Gqi5 Stable Cell
Adrenoceptors are 7-transmembrane receptors which mediate the central and peripheral actions of the neurotransmitter noradrenaline (norepinephrine) and the hormone and neurotransmitter adrenaline (epinephrine) Based on both pharmacological and molecular evidence they are divided into three major types - 1 2 and The 2 adrenoceptors include 3 subtypes - 2A 2B and 2C - each of which couples to G sub i/o /sub protein primarily br The 2B adrenoceptors (ADRA2B) is expressed in the kidney liver brain lung heart and skeletal muscle The development of 2B and 2C knock-out mice has shown that these two subtypes are not involved in the central hypotensive response to 2 agonists
Eurofins Discoverx PathHunter Jurkat ICOS Signaling Assay, 2 vials. (93-1127C19)
The PathHunter ICOS Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. ICOS-L) based activation of ICOS receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged ICOS target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/checkpoint.
Eurofins Discoverx CHO-K1 PTGER1 Gq Cell Line, 2 vials. (95-1003C2)
The PTGER1 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER1, a naturally Gq coupled GPCR. Upon activation of PTGER1, the resulting calcium activity can be fluorescently assayed using the Calcium No WashPLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Sendai virus; Strain: Cantell
Sendai virus strain Cantell is propagated in SPF chicken embryonated eggs. This strain was deposited by the Central Public Health Laboratory, Helsinki, Finland. This product is whole-genome sequenced and is widely used for induction of interferon and cell fusion. It also has applications in infectious and respiratory disease research.
Eurofins Discoverx PathHunter CHO-K1 cyno MRGPRX2 β-Arrestin Cell Line, 2 vials. (93-1134C2)
The PathHunter cyno MRGPRX2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PAMP-20) based activation of cyno MRGPRX2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged cyno MRGPRX2 and EA-tagged β-Arrestin-2. Activation of cyno MRGPRX2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Cynomolgus monkey version of the protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.